Related Experiment Video

Updated: May 12, 2026

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

Finding the right questions: exploratory pathway analysis to enhance biological discovery in large datasets

Thomas Kelder1, Bruce R Conklin, Chris T Evelo

  • 1Department of Bioinformatics, BiGCaT, Maastricht University, Maastricht, The Netherlands. thomaskelder@gmail.com

Plos Biology
|September 9, 2010
PubMed

Abstract:

This Essay discusses the role of pathways for exploratory data analysis in present-day biology.

More Related Videos

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Experiment Videos

Last Updated: May 12, 2026

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Articles linked to this work by shared authors, journal, and citation graph.

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington's disease.

Bioinformatics (Oxford, England)·2026

EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing.

bioRxiv : the preprint server for biology·2026

Integrating transcriptomics and molecular AOPs to identify T3-dependent regulation of neuronal development in the human neural progenitor test.

Toxicology·2026

Discovery and Validation of SVEP1 and Other Novel Cardiovascular Biomarkers For Patients with Kidney Failure On Maintenance Hemodialysis.

medRxiv : the preprint server for health sciences·2026

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles.

medRxiv : the preprint server for health sciences·2026

Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons.

bioRxiv : the preprint server for biology·2026

Eye movements reflect capacity-dependent organization of working memory.

PLoS biology·2026

PrimeStack editors enable efficient and site-specific integration of large multigene cargos in plants.

PLoS biology·2026

An inositol receptor Itr4 coordinates carbon catabolite regulation and virulence in Cryptococcus neoformans.

PLoS biology·2026

Bridging energy and proteome allocation models allows prediction of the resource cost of traits across environments.

PLoS biology·2026

Interindividual vocal tract diversity influences the phonetic diversification of spoken languages.

PLoS biology·2026

Recombination shapes the dynamics of selective constraint in global populations of human gut bacteria.

PLoS biology·2026

RiboBA: a bias-aware probabilistic framework for robust ORF identification across diverse ribosome profiling protocols.

Nucleic acids research·2026

scDGCN: A Graph-Based Deep Clustering Framework for Single-Cell Transcriptomics via Neighborhood-Enhanced Context Representation Learning.

Interdisciplinary sciences, computational life sciences·2026

Interpretable AI model reveals spatial codes of cell recruitment in tissues.

Nature biomedical engineering·2026

BioText-SeqFormer: Integrating biomedical semantic representations and protein sequence embeddings for TCR-peptide interaction prediction.

Computational biology and chemistry·2026

Operational integration of FT-IR spectroscopy into a genomics-based surveillance algorithm for Listeria monocytogenes.

Microbiology spectrum·2026

FAMUS: A Few-Shot Learning Framework for Large-Scale Protein Annotation.

Bioinformatics (Oxford, England)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us