Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pedigree Analysis

Pedigree Analysis

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mortality Trends and Causes of Death in Myotonic Dystrophy Type 1 Patients From the UK Clinical Practice Research Datalink.

Muscle & nerve·2024

Same author

Diagnosing missed cases of spinal muscular atrophy in genome, exome, and panel sequencing data sets.

Genetics in medicine : official journal of the American College of Medical Genetics·2024

Same author

Development of a riboflavin-responsive model of riboflavin transporter deficiency in zebrafish.

Human molecular genetics·2024

Same author

Correction: Phenotype-driven genomics enhance diagnosis in children with unresolved neuromuscular diseases.

European journal of human genetics : EJHG·2024

Same author

Ion Mobility QTOF-MS Untargeted Lipidomics of Human Serum Reveals a Metabolic Fingerprint for GNE Myopathy.

Molecules (Basel, Switzerland)·2024

Same author

Brain malformations and seizures by impaired chaperonin function of TRiC.

Science (New York, N.Y.)·2024

Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026

Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026

Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026

Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Biobanking in rare disorders.

Hanns Lochmüller¹, Peter Schneiderat

¹Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK. hanns.lochmuller@ncl.ac.uk

Advances in Experimental Medicine and Biology

|September 9, 2010

Summary

This summary is machine-generated.

Biobanks provide valuable human samples and data for research, especially for rare disorders. Transnational cooperation and networks enhance biobanking practices and resource sharing for scientific advancement.

More Related Videos

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Related Experiment Videos

Last Updated: Jun 9, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Area of Science:

Biomedical research
Translational science
Rare disease research

Background:

Biobanks are crucial for collecting human biomaterials and associated data.
High-quality biomaterials are essential for fundamental and translational research.
Rare disorder research significantly benefits from specialized biobanking resources.

Purpose of the Study:

To highlight the importance of biobanks in research.
To emphasize the value of human samples for rare disorder studies.
To promote transnational cooperation in biobanking.

Main Methods:

Not explicitly stated in the abstract, but implies the establishment and operation of biobanks and networks.
Facilitating access to biomaterials for researchers.
Ensuring common practices and quality standards across biobanks.

Main Results:

Biobanks provide essential high-quality human biomaterials for research.
Each sample from rare disorder patients is highly valuable for scientific discovery.
Transnational cooperation optimizes resource sharing and research outcomes.

Conclusions:

Biobanking is indispensable for advancing medical research, particularly for rare disorders.
Networks of biobanks are vital for standardizing practices and improving access to rare samples.
Collaborative biobanking efforts accelerate research and facilitate scientific breakthroughs.