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High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons

Kathleen E Cosgrove1, Stephen D Meriney, Germán Barrionuevo

  • 1Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Hippocampus
|September 9, 2010
PubMed
Summary

Group III metabotropic glutamate receptors (mGluRs) 4/8 activation on mossy fiber terminals regulates the timing and probability of action potentials in hippocampal stratum lacunosum-moleculare interneurons (L-Mi). This presynaptic mechanism fine-tunes feedforward inhibition in the CA3 region.

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