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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Updated: Jun 9, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Stem cell transplantation for ischemic stroke.

Giorgio Battista Boncoraglio¹, Anna Bersano, Livia Candelise

¹Department of Neurology, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, Milano, Italy, 20133.

The Cochrane Database of Systematic Reviews

|September 9, 2010

Summary

This summary is machine-generated.

Stem cell transplantation shows no proven benefit for ischemic stroke patients in current small trials. Larger, well-designed studies are necessary to determine the efficacy and safety of this potential stroke treatment.

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Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

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Published on: January 23, 2009

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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

Area of Science:

Neurology
Regenerative Medicine
Clinical Trials

Background:

Animal models suggest stem cell transplantation aids functional recovery after ischemic stroke.
Clinical evidence for stem cell therapy benefits in human ischemic stroke patients remains limited.

Purpose of the Study:

To evaluate the efficacy and safety of stem cell transplantation versus conventional treatments for ischemic stroke patients.

Main Methods:

Systematic review of randomized controlled trials (RCTs) using comprehensive database searches and manual screening.
Inclusion criteria: RCTs of ischemic stroke patients with confirmed lesions, any stem cell type, administration route, or dosage.
Primary outcome: functional improvement at six months; secondary outcomes: safety events like death or infection.

Main Results:

Three small RCTs were identified; two require further data for analysis.
One trial (30 patients) showed non-significant functional improvement with autologous mesenchymal stem cells.
No adverse cell-related events were reported in the analyzed trial.

Conclusions:

Current evidence from limited, small trials is insufficient to confirm stem cell transplantation benefits for ischemic stroke.
Large-scale, well-designed clinical trials are essential to establish the efficacy and safety of stem cell therapy for stroke recovery.