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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: Jun 9, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

Interventions for acute internal hordeolum.

Kristina Lindsley1, Jason J Nichols, Kay Dickersin

  • 1Center for Clinical Trials, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, W5010, Baltimore, Maryland, USA, 21205.

The Cochrane Database of Systematic Reviews
|September 9, 2010
PubMed
Summary
This summary is machine-generated.

No studies evaluated non-surgical treatments for acute internal hordeolum. More research, specifically randomized controlled trials, is needed to determine effective interventions for this common eyelid infection.

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Surgical Correction for Pediatric Epiblepharon and Trichiasis
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Surgical Correction for Pediatric Epiblepharon and Trichiasis
03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Area of Science:

  • Ophthalmology
  • Evidence-Based Medicine
  • Infectious Diseases

Background:

  • Hordeolum is a frequent, painful eyelid inflammation, typically due to bacterial infection of oil glands.
  • Acute internal hordeolum can resolve spontaneously but may lead to complications or recurrences.

Purpose of the Study:

  • To review the effectiveness and safety of non-surgical treatments for acute internal hordeolum.
  • To compare interventions against observation or placebo.

Main Methods:

  • Systematic search of multiple electronic databases including CENTRAL, MEDLINE, EMBASE, LILACS, and clinical trial registries.
  • Inclusion criteria focused on randomized or quasi-randomized trials of acute internal hordeolum, excluding external hordeola, chronic cases, or chalazia.

Main Results:

  • No randomized controlled trials were identified for inclusion in the review.
  • Searches yielded limited relevant literature, primarily concerning external hordeola, chronic conditions, or observational studies/case reports predating current standards.

Conclusions:

  • There is a lack of evidence to support or refute the effectiveness of non-surgical treatments for hordeolum.
  • Further high-quality randomized controlled trials are essential to guide clinical practice for acute internal hordeolum.