Related Experiment Video
Updated: Jun 9, 2026

07:21
The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster
Published on: June 8, 2018
Prediction of resultant testosterone concentrations from flywheel-based resistive exercise
John F Caruso1, Michael A Coday, Skyler T Taylor
1Exercise and Sport Science Program, Ph.D, 312 Chapman Hall, 600 S. College Avenue, The University of Tulsa, Tulsa, OK 74104, USA. john-caruso@utulsa.edu
Aviation, Space, and Environmental Medicine
|September 10, 2010
Summary
Body mass and average power best predict testosterone concentration changes after flywheel ergometer exercise. Monitoring these factors can optimize exercise prescriptions for in-flight training and prevent muscle loss.
Area of Science:
- Exercise Physiology
- Endocrinology
Background:
- Testosterone concentrations (TC) are influenced by various factors, affecting workout efficacy.
- Identifying these factors can inform the development of effective in-flight exercise prescriptions.
Purpose of the Study:
- To identify variables that predict changes in testosterone concentrations (TC) following flywheel ergometer exercise.
- To compare the predictive power of concentric-only versus combined concentric and eccentric muscle actions on TC.
Main Methods:
- Seventeen subjects performed three randomized leg press workouts using a flywheel ergometer: concentric-eccentric (CE3), concentric-only (CO3), and concentric-only (CO6).
- Venous plasma TC were measured pre-exercise and at 1 and 30 minutes post-exercise.
- Multivariate regression analyzed the relationship between body mass, blood lactate, peak angular velocity, average power, total work, and TC variance.
Main Results:
- Predictor variables significantly explained TC variance at 1 and 30 minutes post-exercise for both workout types.
- Eccentric variables (CE3 bout) explained substantially more TC variance (r2 = 0.90) compared to concentric-only workouts (r2 = 0.54).
Conclusions:
- Body mass and average power were the strongest predictors of post-exercise TC variance.
- These findings suggest monitoring body mass and average power for exercise prescriptions using flywheel devices to mitigate muscle atrophy and strength loss.
- Further research is needed to elucidate the role of eccentric actions in explaining TC variance during flywheel ergometer workouts.

