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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

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Related Experiment Video

Updated: Jun 9, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

Functioning and disability in Parkinson's disease.

Alberto Raggi¹, Matilde Leonardi, Daniela Ajovalasit

¹Neurology, Public Health and Disability Unit - Scientific Directorate, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, Milan, 20133 Italy. araggi@istituto-besta.it

Disability and Rehabilitation

|September 10, 2010

Summary

This summary is machine-generated.

This study assessed functioning and disability in Parkinson's Disease (PD) patients using the International Classification of Functioning Disability and Health (ICF) model. Key limitations were identified in mobility and social participation, highlighting the need for comprehensive disability assessment in PD.

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Last Updated: Jun 9, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Area of Science:

Neurology
Rehabilitation Medicine
Public Health

Background:

Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting millions worldwide.
Understanding the multifaceted impact of PD on functioning and disability is crucial for effective patient care and management.
The International Classification of Functioning Disability and Health (ICF) provides a standardized framework for describing health and disability.

Purpose of the Study:

To characterize the functioning and disability profiles of Parkinson's Disease patients.
To apply the International Classification of Functioning Disability and Health (ICF) model to assess PD-related disability.
To identify key areas of limitation in daily life for individuals with Parkinson's Disease.

Main Methods:

Consecutive enrollment of adult Parkinson's Disease patients.
Administration of the ICF checklist and the WHO Disability Assessment Schedule II (WHO-DAS II).
Utilized Hoehn and Yahr Staging (HY) to classify PD severity and performed descriptive analyses.

Main Results:

Ninety-six PD patients (mean age 64.1 years, 33.3% female) were included; 48.4% were in HY class 2.
The mean WHO-DAS II score was 18.1, with the most significant limitations reported in 'getting around' and 'participation in social situations'.
A total of 71 ICF categories were reported as problematic by over 20% of patients, predominantly from the Activities and Participation domains.

Conclusions:

The study provides comprehensive data on functioning and disability across various domains in Parkinson's Disease patients.
Findings underscore the importance of considering a broad spectrum of limitations, including mobility and social engagement, in PD disability assessment.
Results inform the development of expanded disability assessment strategies for PD, integrating symptom, activity, and environmental factor considerations.