Related Experiment Video

Updated: Jun 9, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Prevalence and severity of echocardiographic left ventricular hypertrophy in hypertensive patients in clinical

Cesare Cuspidi1, Francesca Negri, Maria Lorenza Muiesan

  • 1Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy. cesare.cuspidi@unimib.it

Blood Pressure
|September 10, 2010
PubMed

Insights

Left ventricular hypertrophy (LVH) is highly prevalent in hypertensive patients, even with treatment. This study found significant LVH in a large clinical cohort, highlighting the need for continued management strategies.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Limited data exists on left ventricular hypertrophy (LVH) prevalence in clinical practice for hypertension.
  • Previous studies primarily focused on population-based or selected hypertensive cohorts.
  • This study addresses the gap by examining LVH in a large, routine clinical sample.

Purpose of the Study:

  • To determine the prevalence of LVH in hypertensive patients undergoing routine echocardiography.
  • To assess the severity of LVH in this clinical population.
  • To provide insights into LVH burden in everyday hypertension management.

Main Methods:

  • A multicentre study included 2249 hypertensive patients referred for echocardiography.
  • LVH was defined using three established criteria based on left ventricular mass.
  • LVH severity was graded as mild, moderate, or severe.

Main Results:

  • LVH prevalence ranged from 58% to 65% across the different criteria.
  • Mild LVH was observed in 29-33% of patients.
  • Moderate LVH affected 27-31%, and severe LVH was present in 36-44%.

Conclusions:

  • Left ventricular hypertrophy is a frequent finding in hypertensive patients, even those receiving treatment.
  • A substantial proportion of hypertensive patients exhibit severe LVH.
  • These findings underscore the persistent challenge of LVH in hypertension management.
Abstract

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...