[Isolation and comparative study of highly reproductive recombinant influenza A viruses with a high antibody...

The possibility of generating avid and highly reproductive recombinants of influenza A virus (H3N2, H3N1) using strain A/PR/8/34 (H1N1) as a donor of high reproductive activity was demonstrated. In the process of recombination, the transmission of the gene responsible for synthesis of avid hemagglutinin H3 from one virus variant to another provides for high avidity of recombinants. However, a possible influence of other influenza A virus genes on the manifestation of avidity cannot be ruled out.