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Related Experiment Video

Updated: Jun 9, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Ionic liquid based microemulsion with pharmaceutically accepted components: Formulation and potential applications.

Muhammad Moniruzzaman¹, Noriho Kamiya, Masahiro Goto

¹Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan.

Journal of Colloid and Interface Science

|September 10, 2010

Summary

A novel ionic liquid-in-oil microemulsion effectively dissolves poorly soluble pharmaceuticals. This discovery offers a promising new avenue for developing advanced drug delivery systems for challenging drug molecules.

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

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Last Updated: Jun 9, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Area of Science:

Physical Chemistry
Materials Science
Pharmaceutical Sciences

Background:

Many pharmaceuticals exhibit poor solubility in conventional solvents, hindering their therapeutic efficacy.
Developing effective drug delivery systems for poorly soluble drugs remains a significant challenge in pharmaceutical research.

Purpose of the Study:

To develop a novel ionic liquid-in-oil (IL/o) microemulsion capable of dissolving pharmaceuticals with low solubility.
To investigate the potential of this microemulsion as a drug carrier system.

Main Methods:

Formation of nanometer-sized ionic liquid droplets in isopropyl myristate using nonionic surfactants (Tween-80 and Span-20).
Ternary phase behavior studies to confirm microemulsion stability and composition.
Dynamic light scattering (DLS) for characterizing droplet size and shape.
Solubility studies of model drug molecules within the developed IL microemulsion.

Main Results:

Optically transparent and thermodynamically stable IL/o microemulsions were successfully formed across a wide range of ionic liquid content.
Dynamic light scattering confirmed the formation of spherical micelles with sizes ranging from 8-34 nm.
Significant solubilization of poorly soluble drugs (acyclovir, methotrexate, etc.) was observed in the ionic liquid microemulsions.

Conclusions:

The developed ionic liquid-in-oil microemulsion demonstrates excellent potential for dissolving and carrying poorly soluble pharmaceutical compounds.
Ionic liquids with coordinating anions that are strong hydrogen bond acceptors are most effective for microemulsion formation.
This novel microemulsion system offers new opportunities for developing advanced drug delivery carriers for challenging drug molecules.