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Updated: Jun 9, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

T cells that trigger acute experimental autoimmune encephalomyelitis also mediate subsequent disease relapses and

Jinzhu Li1, Xiaoqing Zhao, Hui-Wen Hao

  • 1Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Journal of Neuroimmunology
|September 10, 2010
PubMed

Earlier studies showed that donor T cells that initiated a murine adoptive EAE persisted in the CNS of the recipients throughout the subsequent relapsing cycles. To clarify the functions of the persistent donor T cells in EAE relapsing disease, anti-Thy-1 antibodies were used to deplete these cells. Results showed that such treatment abrogated subsequent relapsing cycles in these animals. In addition, it was evident that a shift in cytokine profile occurred during acute and relapsing disease phases. These results unambiguously support the appropriateness of targeting T cells with specificity for the priming antigen in design of therapeutic approaches for MS.

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