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Updated: Jun 9, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
[Gut translocation septicemia in infant]
E Jeziorski1, C Ludwig, M Rodière
1Service de pédiatrie infectieuse et générale, Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France.
Insights
Bacterial translocation in children can cause severe invasive infections. Early etiological diagnosis and preventive measures are crucial for managing these serious conditions.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Gastroenterology
Abstract:
Intestinal microbiotype necessary for life is a source of complications in childhood. Bacterial translocation is responsible of endogenous septicaemia and invasive complications. We report five cases of severe invasive infections associated with diarrhoea, digestive bleeding or sepsis. Biological parameters for inflammation are highly positive, and blood cultures reveal bacterial identification: salmonella enteridis, enterobacter cloacae, campylobacter jejuni, escherichia coli or clostridium difficile. We describe the predisposing factors and susceptibility status to develop translocation: invasive diarrhoea, asplenia, gasto-intestinal disease… All invasive infections in children require etiological approach with the possibility of an endogenous septicaemia (bacterial translocation). This approach minimises the nosocomial features undercurrent in these invasive infections, and leads also to other alternative preventive measures: antibiotic association, maintaining an enteral nutrition, pre or probiotic use, specific digestive decontamination.
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