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[Multiple brain abscesses complicating Enterobacter cloacae sepsis in a premature infant]

P Traoré1, S Coquery, V Zupan-Simunek

  • 1Service de pédiatrie et réanimation néonatales, Hôpital Antoine Béclère, 157, Rue de la porte des Trivaux, 92240 Clamart, France. numasso@yahoo.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 10, 2010
PubMed

Insights

A premature infant with Enterobacter cloacae neonatal infection developed cerebral abscesses. Treatment with cefepime and ciprofloxacin led to complete regression, with normal neurodevelopmental outcome. Ciprofloxacin use in neonates is discussed.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatric Neurology

Background:

  • Neonatal infections pose significant risks to premature infants.
  • Enterobacter cloacae is a potential cause of serious neonatal infections.
  • Cerebral abscesses are a rare but severe complication of neonatal sepsis.

Observation:

  • A premature infant diagnosed with Enterobacter cloacae infection at 21 days.
  • Five cerebral abscesses were identified despite initial cefotaxime and amikacin treatment.
  • Treatment was switched to cefepime and ciprofloxacin, leading to abscess regression.

Findings:

  • Successful management of neonatal Enterobacter cloacae cerebral abscesses was achieved.
  • A combination of cefepime and ciprofloxacin therapy resulted in complete regression of abscesses.
  • The infant exhibited a normal neurodevelopmental outcome at 13 months of age.

Implications:

  • This case highlights the potential efficacy of cefepime and ciprofloxacin in treating neonatal Enterobacter cloacae brain infections.
  • It supports the consideration of ciprofloxacin for specific neonatal infections when standard treatments are insufficient.
  • Further discussion on the indications and safety of ciprofloxacin in the neonatal period is warranted.

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