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Updated: Jun 9, 2026

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
Published on: January 10, 2025
Detection, evaluation, and management of iron-restricted erythropoiesis
Lawrence Tim Goodnough1, Elizabeta Nemeth, Tomas Ganz
1Departments of Pathology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. ltgoodnough@stanfordmed.org
Abstract:
Progress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. Newer assays for markers of inflammation may allow more targeted management of the anemia in these conditions. The availability of new intravenous iron preparations provides new options for the treatment of iron-restricted erythropoiesis. This review summarizes recent advances regarding the detection, evaluation, and management of iron-restricted erythropoiesis.
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