Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity

Sunggeon Ko1, Gil Bu Kang, Sung Min Song

  • 1Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.

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The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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