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Related Concept Videos

Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
What are Lipids?01:38

What are Lipids?

Overview
What are Lipids?01:31

What are Lipids?

Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
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Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and carbon-hydrogen bonds...
Membrane Lipids01:32

Membrane Lipids

Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Membrane Lipids01:32

Membrane Lipids

Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

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Related Experiment Video

Updated: Jun 9, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

Modified phospholipids as anti-inflammatory compounds.

Erez Feige1, Itzhak Mendel, Jacob George

  • 1VBL Therapeutics, Or Yehuda, Israel.

Current Opinion in Lipidology
|September 10, 2010
PubMed
Summary
This summary is machine-generated.

Oxidized phospholipids (OxPLs) can surprisingly reduce inflammation by inhibiting immune cell activation. This discovery opens new avenues for treating chronic inflammatory diseases with OxPL-based therapies.

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Defining Substrate Specificities for Lipase and Phospholipase Candidates
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Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

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Last Updated: Jun 9, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Area of Science:

  • Immunology
  • Pharmacology
  • Biochemistry

Background:

  • Oxidized phospholipids (OxPLs) are found at inflammation sites and influence immune responses.
  • While often considered pro-inflammatory, some OxPLs exhibit anti-inflammatory properties.
  • Understanding these dual roles is crucial for therapeutic development.

Purpose of the Study:

  • To review the pro- and anti-inflammatory effects of OxPLs.
  • To explore the therapeutic potential of OxPL derivatives for chronic inflammatory disorders.

Main Methods:

  • Literature review of studies on OxPLs and their effects on immune cells.
  • Analysis of preclinical and clinical data on OxPL analogs.

Main Results:

  • OxPLs can inhibit Toll-like receptor activation and dendritic cell maturation, demonstrating anti-inflammatory effects.
  • The synthetic phospholipid analog VB-201 reduced inflammation in preclinical models and is in Phase II clinical trials for psoriasis.

Conclusions:

  • Modifying phospholipids can yield anti-inflammatory compounds.
  • Developing stable and potent OxPL variants offers a novel therapeutic strategy for immune-mediated diseases like psoriasis, atherosclerosis, multiple sclerosis, and rheumatoid arthritis.