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Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Videos

Pathogenic mechanisms shared between psoriasis and cardiovascular disease.

Ramin Ghazizadeh1, Hajime Shimizu, Mamiko Tosa

  • 1Academic Dermatology and Skin Cancer Institute, Chicago, Illinois 60602, USA. rghazi1@lycos.com

International Journal of Medical Sciences
|September 10, 2010
PubMed
Summary

Psoriasis and atherosclerosis share common inflammatory pathways. Targeting inflammation and hyperlipidemia may offer dual therapeutic benefits for both conditions.

Keywords:
atherosclerosiscardiovascular diseasepsoriasisshared pathogenic mechanism

Related Experiment Videos

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is linked to a higher risk of cardiovascular disease, particularly atherosclerosis.
  • Shared pathogenic mechanisms between psoriasis and atherosclerosis warrant investigation for early intervention.

Purpose of the Study:

  • To review literature on common pathogenic mechanisms between psoriasis and atherosclerosis.
  • To advocate for early therapeutic or preventive strategies targeting shared pathways.

Main Methods:

  • Literature review of biomedical databases.
  • Focus on common developmental processes in psoriasis and atherosclerosis.

Main Results:

  • Inflammation is a key shared pathogenic mechanism.
  • Immune cell activation (T-cells, antigen-presenting cells) and adhesion molecules (LFA-1, ICAM-1) play crucial roles.
  • Inflammatory processes lead to psoriatic and atherosclerotic plaque formation.
  • Hyperlipidemia treatment shows potential benefits for psoriasis.

Conclusions:

  • Shared inflammatory pathways underscore the link between psoriasis and atherosclerosis.
  • Combined strategies reducing hyperlipidemia and suppressing inflammation may effectively manage both diseases.