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Papillary Dermis

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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Pseudoxanthoma elasticum papillary dermal elastolysis: a case report.

Rubina Alves¹, Lurdes Ferreira, Esmeralda Vale

¹Department of Dermatology, Hospital Central of Funchal, Estrada dos Marmeleiros Monte, 9054-535 Funchal, Madeira, Portugal.

Dermatology Research and Practice

|September 10, 2010

Summary

This summary is machine-generated.

Pseudoxanthoma Elasticum-like Papillary Dermal Elastolysis (PXE-PDE) is a rare skin condition causing yellow papules. Diagnosis involves histopathology showing absent papillary dermal elastic fibers, with no current effective treatment.

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Area of Science:

Dermatology
Pathology

Background:

Pseudoxanthoma Elasticum-like Papillary Dermal Elastolysis (PXE-PDE) is a rare clinicopathological entity.
It primarily affects elderly women, presenting as asymptomatic, bilateral, symmetrical yellowish papules on the neck and supraclavicular areas.

Observation:

A case report details a 64-year-old woman with asymptomatic, yellowish, non-follicular papules on the neck for one year.
The patient reported no pruritus, inflammation, significant sun exposure, or trauma.
Routine laboratory, thoracic X-ray, and ophthalmologic examinations were normal.

Findings:

Histopathologic examination revealed an absence of elastic fibers in the papillary dermis.
The diagnosis of PXE-PDE was established based on these findings.
Differential diagnosis includes Pseudoxanthoma Elasticum (PXE), Mid-dermal Elastolysis (MDE), Linear Focal Elastosis (LFE), and White Fibrous Papulosis of the Neck (WFPN).

Implications:

This case highlights the importance of accurate diagnosis of PXE-PDE.
It underscores the need to differentiate PXE-PDE from other elastolytic disorders.
Currently, there is no established effective treatment for PXE-PDE.