Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Printed Organic Memristive Device on Rigid and Flexible Supports for Neuromorphic Applications.

Biomimetics (Basel, Switzerland)·2026
Same author

A Printable OECT for Simple Integration in Nitrocellulose-Based Assays.

ACS sensors·2025
Same author

A Review on Laser-Induced Graphene-Based Electrocatalysts for the Oxygen Reduction Reaction in Electrochemical Energy Storage and Conversion.

Nanomaterials (Basel, Switzerland)·2025
Same author

Droplet Generation and Manipulation in Microfluidics: A Comprehensive Overview of Passive and Active Strategies.

Biosensors·2025
Same author

Laser-Induced Graphene Electrodes for Flexible pH Sensors.

Nanomaterials (Basel, Switzerland)·2024
Same author

Ultrasound-assisted water oxidation: unveiling the role of piezoelectric metal-oxide sonocatalysts for cancer treatment.

Biomedical microdevices·2024
Same journal

A pump-free gravity-driven microfluidic chip for rapid RPA-LFS-based detection of Magnaporthe oryzae AvrPi9 gene.

Biomedical microdevices·2026
Same journal

Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours.

Biomedical microdevices·2026
Same journal

Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.

Biomedical microdevices·2026
Same journal

3D printed chip as platform to vascularize hiPSCs-derived kidney organoids.

Biomedical microdevices·2026
Same journal

Ingestible smart capsules: from engineering innovation to GI drug delivery.

Biomedical microdevices·2026
Same journal

An inexpensive, portable, refrigeration-free, ready-to-use microfluidic device for real-time multiplexed molecular detection of HIV, HBV, and HCV.

Biomedical microdevices·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

A multilevel Lab on chip platform for DNA analysis.

Simone Luigi Marasso1, Eros Giuri, Giancarlo Canavese

  • 1Xlab-Materials and Microsystems Laboratory, Department of Material Science and Chemical Engineering, Politecnico di Torino-Latemar Unit, Via Lungo Piazza d'Armi 6, 10034 Chivasso, Turin, Italy. simone.marasso@polito.it

Biomedical Microdevices
|September 10, 2010
PubMed
Summary
This summary is machine-generated.

This study presents a novel lab-on-chip (LOC) integrating microfluidics and DNA microarrays. The developed LOC system automates biological protocols, significantly reducing analysis time and reagent use.

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

DNA-based Fish Species Identification Protocol
09:15

DNA-based Fish Species Identification Protocol

Published on: April 28, 2010

Related Experiment Videos

Last Updated: Jun 9, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

DNA-based Fish Species Identification Protocol
09:15

DNA-based Fish Species Identification Protocol

Published on: April 28, 2010

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Molecular Biology

Background:

  • Traditional biological and biomedical analyses are time-consuming and costly.
  • Lab-on-chips (LOCs) offer a promising solution for faster, more economical testing.
  • Integrating microfluidic devices with microarray technology presents unique engineering and biological challenges.

Purpose of the Study:

  • To design, fabricate, and test a complex multilevel analysis platform integrating microarray technology and microfluidic devices.
  • To develop a disposable LOC system for automated biological protocols.
  • To address microfluidic and handling challenges in integrated systems.

Main Methods:

  • Utilized Micro Electro Mechanical Systems (MEMS) materials and processes.
  • Fabricated a silicon/glass microfluidic chip and a Polydimethylsiloxane (PDMS) reaction chamber.
  • Interfaced microfluidic channels with standard DNA microarray glass slides.
  • Employed passive micro-elements with an external apparatus for fluidic driving and thermal control.

Main Results:

  • Successfully interfaced microfluidic channels with DNA microarray slides.
  • Developed innovative solutions for microfluidic and handling challenges.
  • Demonstrated an entirely automated DNA hybridization protocol.
  • Achieved significant reductions in analysis time and reagent consumption compared to conventional methods.

Conclusions:

  • The developed LOC platform enables efficient integration of microfluidics and DNA microarrays.
  • The system offers a cost-effective and time-saving solution for biological analyses.
  • This technology has the potential to streamline complex biological protocols in research and diagnostics.