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Related Experiment Videos

[Tracheobronchial carcinoids: current therapeutic trends].

A Di Giorgio, A Tocchi, G Puntillo

    Annali Italiani Di Chirurgia
    |July 1, 1990
    PubMed
    Summary

    Surgical management of tracheobronchial carcinoids offers cure, but optimal extent remains debated. Major surgery yields lower recurrence than limited resections, with prognosis tied to tumor grade and metastasis.

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    Area of Science:

    • Pulmonary Medicine
    • Surgical Oncology
    • Pathology

    Context:

    • Tracheobronchial carcinoids are rare neuroendocrine tumors.
    • Surgical treatment is potentially curative but optimal extent is debated.
    • Review of 522 cases including 52 from a single institution (1960-1983).

    Purpose:

    • To evaluate the impact of surgical extent on local recurrence and long-term survival in tracheobronchial carcinoids.
    • To identify prognostic factors influencing tumor control.

    Summary:

    • Local recurrence rates varied: 1-1.8% after major surgery (pneumonectomy/lobectomy/sleeve resection), 11.8-16.7% after bronchial wall resection or endoscopic treatment.
    • 15-year survival exceeded 70%. Prognosis correlated with tumor malignancy (typical vs. atypical), nodal (N), and distant (M) metastases.

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  • Surgical margins, bronchial wall involvement, tumor biology, and metastasis presence are key prognostic indicators.

    • Impact:

    • Findings guide surgical strategy: limited resections for typical endobronchial carcinoids, extended resection with lymphadenectomy for atypical or invasive tumors.
    • Highlights the importance of aggressive surgical management for better long-term outcomes in tracheobronchial carcinoids.