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[Preparation of derivatives of the aldehydic functions of gossypol]
N Kunesch1, M P Barbier, A Dalkafouki
1Laboratoire de Chimie des Substances thérapeutiques naturelles, UA CNRS n. 496, Centre d'Etudes pharmaceutiques, Châtenay-Malabry.
Annales Pharmaceutiques Francaises
|January 1, 1990
Abstract:
Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.