Catalyst-free one-pot four component synthesis of polysubstituted imidazoles in neutral ionic liquid
Alireza Hasaninejad1, Abdolkarim Zare, Mohsen Shekouhy
1Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran. ahassaninejad@yahoo.com
Abstract:
A catalyst-free one-pot four component methodology for the synthesis of 1,2,4,5-substituted imidazoles under conventional heating and microwave irradiation using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction media is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and/or electron releasing groups as well as heteroaromatic aldehydes) and primary amines (aromatic and aliphatic) were applied successfully, and corresponding products were obtained in good to excellent yields without any byproduct.
Related Concept Videos
Radical Substitution: Allylic Bromination
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Preparation and Reactions of Sulfides
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...


