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Updated: Jun 9, 2026
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Biomarkers for late-onset neonatal sepsis
Richard A Polin1, Tara M Randis
1Columbia University College of Physicians and Surgeons, Division of Neonatology, NY Presbyterian Morgan Stanley Children's Hospital, 3959 Broadway, CHC 115, New York, NY 10032, USA. rap32@columbia.edu.
Abstract:
The diagnosis of healthcare-associated infections is problematic because of the overlap between clinical signs associated with 'normal' physiological disturbances and those of bacteremia or fungemia. Earlier diagnosis of sepsis in critically ill infants would enable timely administration of antibiotics and discontinuation of treatment in infants with a low probability of sepsis. A recent study by Ng et al. identified two novel biomarkers for late-onset neonatal sepsis: the des-arginine variant of serum amyloid A and apolipoprotein C-II. These markers may be of value in the identification of neonates with bacteremia or fungemia.
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