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Expression of aquaporin-1 in nasopharyngeal cancer tissues
1Department of Otolaryngology-Head and Neck Surgery, and Bao Zhang: Molecular Biology Laboratory, Southern Medical University, Guangzhou, Guangdong, PR China.
Objective:
To investigate the expression of aquaporin-1 (AQP1) in nasopharyngeal tumour and nontumour tissues.
Method:
Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction (RT-PCR) to detect the expression level of AQP1 in tissues.
Results:
Immunohistochemistry data suggested that AQP1 was expressed in both nasopharyngeal tumour and normal tissues, but tumour tissues were stained a lot stronger than nontumour tissues. RT-PCR analysis further confirmed the overexpression of AQP1 in tumour tissues; migrated tumour tissue had even higher expression.
Conclusion:
The expression level of aquaporin-1 in nasopharyngeal cancer tissue could be involved in tumour migration.
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