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Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: Jun 9, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

B-cell tolerance: mechanisms and implications.

Antony Basten1, Pablo A Silveira

  • 1Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. A.Basten@garvan.org.au

Current Opinion in Immunology
|September 11, 2010
PubMed
Summary
This summary is machine-generated.

Understanding B-cell tolerance is crucial for treating autoimmune diseases and in transplantation. New insights reveal molecular mechanisms of B-cell tolerance induction and defects contributing to disease.

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Published on: August 12, 2017

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Molecular Biology
  • Autoimmunity

Background:

  • B-cell activities are central to immune responses.
  • B-cell inhibitors show clinical efficacy in autoimmunity and transplantation.
  • Tolerance to self and foreign antigens is vital for B-cell repertoire health.

Purpose of the Study:

  • To highlight the importance of B-cell tolerance.
  • To explore molecular mechanisms of B-cell tolerance induction.
  • To identify B-cell defects in autoimmune/inflammatory diseases.

Main Methods:

  • Review of recent advances in B-cell immunology.
  • Analysis of clinical data on B-cell inhibitors.
  • Investigation of molecular pathways in B-cell tolerance.

Main Results:

  • Advances in understanding B-cell functions.
  • Emerging data on molecular mechanisms of B-cell tolerance.
  • Identification of B-cell selective defects linked to pathogenesis.

Conclusions:

  • B-cell tolerance is critical in autoimmunity and transplantation.
  • Understanding B-cell defects offers therapeutic targets.
  • Further research into B-cell tolerance mechanisms is warranted.