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B-cell tolerance: mechanisms and implications

Antony Basten1, Pablo A Silveira

  • 1Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. A.Basten@garvan.org.au

Current Opinion in Immunology
|September 11, 2010
PubMed

Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases.

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