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Lipids and thrombosis.

J A Gasser, D J Betteridge

    Bailliere'S Clinical Endocrinology and Metabolism
    |December 1, 1990
    PubMed
    Summary
    This summary is machine-generated.

    Plasma lipoproteins, especially oxidized LDL, interact with platelets, causing abnormal function in hypercholesterolemia. These interactions suggest potential benefits from lipid-lowering and dietary therapies.

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    Area of Science:

    • Biochemistry
    • Cardiovascular Biology
    • Hematology

    Background:

    • Plasma lipoproteins and platelet function are known to interact significantly.
    • Hypercholesterolemia is associated with abnormal platelet function, mediated by lipoprotein binding to surface receptors.

    Purpose of the Study:

    • To explore the interactions between plasma lipoproteins and platelet function.
    • To understand the mechanisms behind abnormal platelet function in hypercholesterolemia.
    • To highlight therapeutic implications of these interactions.

    Main Methods:

    • Review of existing evidence on lipoprotein-platelet interactions.
    • Analysis of the impact of altered plasma lipid levels on platelet membrane composition.
    • Examination of effects on transmembrane signaling and receptor binding.

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    Main Results:

    • Oxidized low-density lipoprotein (LDL) binding to platelet surface receptors contributes to abnormal platelet function.
    • Elevated plasma lipid levels alter platelet membrane cholesterol:phospholipid ratio, affecting microviscosity.
    • Changes in microviscosity may impact transmembrane signaling and receptor interactions.

    Conclusions:

    • Lipoprotein interactions significantly influence platelet function, particularly in hypercholesterolemia.
    • Understanding these mechanisms has therapeutic implications for lipid-lowering and dietary interventions.
    • Further research into these interactions could lead to improved cardiovascular disease management.