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Insulin resistance in children: consensus, perspective, and future directions

Claire Levy-Marchal1, Silva Arslanian, Wayne Cutfield

  • 1Institut National de la Santé et de la Recherche Médicale, Unité 690, Hôpital Robert Debré, Université Paris Diderot, 75013 Paris, France.

The Journal of Clinical Endocrinology and Metabolism
|September 11, 2010
PubMed

Insights

Insulin resistance in children is a growing concern linked to cardiometabolic risk. Current screening methods lack justification, but lifestyle changes can improve insulin sensitivity.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Childhood Obesity

Background:

  • Insulin resistance is increasingly prevalent in children and adolescents.
  • It is associated with significant cardiometabolic risk factors.
  • Current understanding and management strategies require clarification.

Framework:

  • A consensus conference addressed key issues in pediatric insulin resistance.
  • Working groups focused on definition, measurement, risk factors, prevention, and treatment.
  • International scientific societies provided support and expertise.

Implementation:

  • Literature reviews informed group discussions and document finalization.
  • A systematic search identified relevant articles on pediatric insulin resistance.
  • Debates and agreements were reached during a 3-day meeting.

Implications:

  • Clear diagnostic criteria for pediatric insulin resistance are lacking.
  • Surrogate markers like fasting insulin are unreliable for assessing insulin sensitivity.
  • Screening children for insulin resistance is not currently recommended.
  • Lifestyle interventions (diet, exercise) are effective for improving insulin sensitivity.
  • Pharmacological treatment should be reserved for select cases.
Abstract

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