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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug

Ryan E Morgan1, Michael Trauner, Carlo J van Staden

  • 1Department of Comparative Biology and Safety Sciences Amgen Inc., Thousand Oaks, California 91320, USA.

Toxicological Sciences : an Official Journal of the Society of Toxicology
|September 11, 2010
PubMed
Summary

This study shows that interference with the bile salt export pump (BSEP) is strongly linked to human liver injury. Understanding BSEP inhibition helps predict and prevent drug-induced liver toxicity often missed in animal models.

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