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Updated: Jun 8, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Dementia developing in late-onset and treatment-refractory obsessive-compulsive disorder
Ilana Frydman1, Rafael Ferreira-Garcia, Manuela C Borges
1Anxiety and Depression Research Program, Institute of Psychiatry, Universidade Federal of Rio de Janeiro, Ipanema, Rio de Janeiro, RJ, Brazil.
Late-onset obsessive-compulsive disorder (OCD) that is resistant to treatment may signal underlying neurological issues. This case report highlights a patient whose treatment-refractory late-onset OCD preceded significant cognitive decline, suggesting a link to dementia.
Area of Science:
- Neuroscience
- Psychiatry
- Gerontology
Background:
- Limited research exists on late-onset obsessive-compulsive disorder (OCD).
- Understanding the pathophysiology of late-onset OCD is crucial for effective treatment.
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