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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Related Experiment Video

Updated: Jun 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Solar elastotic material in dermal lymphatics and lymph nodes.

Melissa P Pulitzer1, Pedram Gerami, Klaus Busam

  • 1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. pulitzem@mskcc.org

The American Journal of Surgical Pathology
|September 11, 2010
PubMed
Summary

Passive mechanical transport explains benign tissue in lymph nodes. This study found solar elastotic material in lymph nodes, supporting the concept of benign and malignant tissue transport via lymphatics.

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Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Related Experiment Videos

Last Updated: Jun 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Oncology

Background:

  • The presence of benign heterotopic tissues in lymph nodes is often attributed to passive mechanical transport through lymphatic channels.
  • Historically, the concept of benign mechanical transport has faced controversy.
  • Establishing this concept is crucial for differentiating benign findings from clinically significant metastatic disease in sentinel lymph nodes.

Purpose of the Study:

  • To investigate the presence and distribution of solar elastotic material within lymph nodes.
  • To provide further evidence supporting the mechanism of passive mechanical transport of tissues through lymphatics.
  • To underscore the importance of this mechanism in interpreting cellular deposits within lymph nodes.

Main Methods:

  • Histopathological examination of lymph node biopsies from 9 patients.
  • Identification and characterization of solar elastotic material within various lymph node compartments.
  • Correlation of findings with patient diagnoses, including cutaneous melanoma and Merkel cell carcinoma.

Main Results:

  • Previously undescribed finding of solar elastotic material in the dermal lymphatics, capsules, subcapsular sinuses, and parenchyma of lymph nodes in 9 patients.
  • Solar elastotic material was observed in lymph nodes associated with metastatic melanoma, melanocytic nevi, and in lymph nodes without other extrinsic cells.
  • Demonstrated passive transport of material into all lymph node compartments.

Conclusions:

  • The findings support the concept of mechanical transport of both benign and malignant tissues via lymphatics.
  • Passively transported material, such as solar elastotic material, can be found in any lymph node compartment.
  • This provides a sound explanation for benign cellular deposits in lymphoid tissue, supporting the assertion that some deposits are not indicative of metastatic disease.