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Updated: Jun 8, 2026
07:55
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
Herpes simplex vegetans presenting as an eyelid mass.
Lauren S Blieden1, Patricia Chévez-Barrios, Michael T Yen
1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, U.S.A.
Ophthalmic Plastic and Reconstructive Surgery
|September 11, 2010
Summary
Herpes simplex vegetans, a rare skin infection, can mimic rapidly growing masses in immunocompromised individuals. Early diagnosis and antiviral treatment are crucial for resolution.
Area of Science:
- Dermatology
- Virology
- Immunology
Background:
- Congenital T-cell immunodeficiency compromises the immune system, increasing susceptibility to opportunistic infections.
- Cutaneous masses in immunocompromised patients warrant thorough investigation due to the potential for unusual or aggressive pathologies.
Observation:
- A 16-year-old girl with T-cell immunodeficiency developed a recurrent lower eyelid mass.
- Histologic examination revealed herpes simplex virus types 1 and 2 infection with significant inflammation and granulation tissue.
Findings:
- The patient was diagnosed with herpes simplex vegetans, a rare ulcerative skin condition.
- Complete resolution of lesions was achieved with the antiviral medication valacyclovir.
Implications:
- Herpes simplex vegetans should be considered in the differential diagnosis of rapidly growing skin lesions in immunocompromised patients.
- Prompt diagnosis and antiviral therapy are essential for managing this condition and preventing recurrence.
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