Toxicology of fluorine-containing monomers

Fluorine-containing monomers form the basis for production of a large number of commercially important polymers. Most of the polymerization occurs as gas-phase reactions, hence the hazards associated with the monomers arises primarily from inhalation. The chemicals covered in this review include bromotrifluoroethylene (BTFE), chlorotrifluoroethylene (CTFE), hexafluoroacetone (HFA), hexafluoroisobutylene (HFIB), hexafluoropropylene (HFP), perfluorobutylene (PFBE), tetrafluoroethylene (TFE), trichloropropene (TFP), vinyl fluoride (VF), and vinylidene fluoride (VF2). The amount of toxicologic information available on the compounds is relatively small and for certain of these the information consists is short-term or acute, hence the current need to make predictions of biologic activity based on analogy or chemical reactivity is great. In animal models and in man, these monomers may be absorbed into the body at varying rates and the metabolism ranges from extensive to little in a species, dose, and chemical specific fashion. The major toxicologic target of these materials is the kidney, and the degree of involvement depends greatly on the excretion patterns and metabolic profiles of the monomers. However, other target sites exist, such as the reproductive system for HFA, making the use of structure-activity relationships difficult.