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DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and

Miao-Ping Chien1, Matthew P Thompson, Nathan C Gianneschi

  • 1Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Chemical Communications (Cambridge, England)
|September 11, 2010
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...