Differences in endocochlear potentials in response to anoxia in maturing and mature guinea pigs

Endocochlear potential (EP) responses to anoxia in immature and mature guinea pigs were compared. The EP decreased much more slowly after anoxia in guinea-pig embryos than in neonates. In many of the embryos, the EP failed to reach any negative voltage. These findings show that the development of the negative component of the EP is a function of the maturation of its positive component.