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Related Concept Videos

Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of the GI tract...
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: Jun 8, 2026

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
10:34

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

Neurogenesis in the enteric nervous system.

Marco Metzger1

  • 1Translational Centre for Regenerative Medicine (TRM) Leipzig, University of Leipzig, Germany. mmetzger@trm.uni-leipzig.de

Archives Italiennes De Biologie
|September 14, 2010
PubMed
Summary

The enteric nervous system (ENS) has stem cells in the gut, similar to the brain. Understanding these enteric stem cells is key for developing new treatments for gut disorders.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Developmental Biology

Background:

  • The enteric nervous system (ENS) is crucial for gastrointestinal function throughout life.
  • Dysfunctions in the ENS can severely impact health and quality of life.
  • Neural stem cells persist in the postnatal gut, analogous to brain stem cells.

Purpose of the Study:

  • To review recent advances in enteric neurogenesis.
  • To provide an overview of ENS development, structure, and function.
  • To discuss developmental and age-related ENS disturbances.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Synthesis of current knowledge on enteric stem cells and neurogenesis.
  • Analysis of ENS development and disease-related alterations.

More Related Videos

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors
08:26

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
07:53

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
10:34

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors
08:26

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
07:53

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Main Results:

  • Enteric stem cells in the postnatal gut show parallels to neural stem cells in the brain.
  • These cells offer potential for cell-based therapies in neurogastrointestinal diseases.
  • A deeper understanding of enteric stem cells is vital for clinical translation.

Conclusions:

  • Enteric stem cells represent a promising therapeutic target for gastrointestinal disorders.
  • Further research into enteric neurogenesis is essential for advancing regenerative medicine.
  • Comprehensive knowledge of ENS development and function aids in treating related diseases.