Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between psychological symptoms and dietary diversity among pregnant and postpartum women in rural areas of Western China.

Journal of affective disorders·2026

Same author

Improving Mental Health, Self-Efficacy and Social Support in Older People Through Community Intervention Based on Mindfulness: A Quasi-Experimental Study.

Healthcare (Basel, Switzerland)·2026

Same author

Impact of Face-to-Face and Online Mindfulness-Based Public Health Interventions on Health-Related Quality of Life in Older People: A Comparative Study.

International journal of environmental research and public health·2025

Same author

Longitudinal associations between perceived father and grandparent support of mothers in early childhood, and maternal mental health.

Frontiers in psychiatry·2025

Same author

Long-term effects of a primary school-based overweight preventive intervention on physical fitness and physical activity: a propensity score-matched retrospective cohort study within the Generation R Study.

BMJ open·2025

Same author

Associations Between Personality Traits, Self-Efficacy and Complementary Feeding Behavior Among Infant Caregivers in Western Rural China.

Maternal & child nutrition·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma research and randomized controlled trials: a remarkable phenomenon.

Esther Hafkamp-de Groen¹, Hein Raat

¹Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands. e.hafkamp@erasmusmc.nl

The Journal of Asthma : Official Journal of the Association for the Care of Asthma

|September 14, 2010

Summary

The number of published randomized controlled trials (RCTs) for asthma research remained nearly constant between 1990 and 2009, despite a significant rise in overall asthma publications. This indicates challenges for evidence-based asthma medicine.

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Related Experiment Videos

Last Updated: Jun 8, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Area of Science:

Pulmonary Medicine
Clinical Research Methodology

Background:

The trend in randomized controlled trial (RCT) publications for asthma research has not been previously analyzed.
Assessing publication trends is crucial for understanding research focus and impact.

Purpose of the Study:

To evaluate the time trends in the number of published RCTs in asthma research from 1990 to 2009.
To compare the publication trends of RCTs with the overall publication trends in asthma research.

Main Methods:

A comprehensive search of the PubMed database was conducted for publications related to asthma.
Data were collected annually from 1990 to 2009.
Publication counts were analyzed for total asthma research and specifically for RCTs in asthma.

Main Results:

The total number of asthma research publications significantly increased from 2240 in 1990 to 5601 in 2009.
In contrast, the number of published RCTs in asthma research showed minimal change, with 198 in 1990 and 233 in 2009.
This represents a disproportionate increase in non-RCT publications compared to RCTs.

Conclusions:

Despite a substantial rise in overall asthma research output, the number of published RCTs has remained relatively stagnant.
This phenomenon may be linked to criticisms of RCT methodology or application in asthma research.
Evidence-based medicine in asthma faces persistent challenges, as indicated by the stalled growth in high-level evidence publication.