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Cutaneous epidermal growth factor receptor system following ultraviolet irradiation: exploring the role of molecular

P A Martínez-Carpio1, M A Trelles

  • 1Research Unit, IMC-Investiláser, Sabadell, Barcelona, Spain.

Photodermatology, Photoimmunology & Photomedicine
|September 14, 2010
PubMed
Abstract

Insights

Ultraviolet (UV) light activates the epidermal growth factor receptor (EGFR) pathway in skin through direct and indirect molecular mechanisms. This review clarifies the UV-EGFR system

Area of Science:

  • Dermatology
  • Molecular Biology
  • Photobiology

Background:

  • The epidermal growth factor receptor (EGFR) pathway is crucial in various skin disorders.
  • Ultraviolet (UV) irradiation is known to activate EGFR in animal and human skin.
  • The precise molecular mechanisms underlying UV-induced EGFR activation are not fully understood.

Purpose of the Study:

  • To review and analyze the molecular mechanisms of UV-induced EGFR activation in the skin.
  • To elucidate the role of the EGFR pathway in cutaneous responses to UV radiation.

Main Methods:

  • A systematic review and analysis of original research papers.
  • Literature search conducted on the MEDLINE database (PubMed) from 1988 to 2009.
  • Selection and detailed examination of 32 relevant citations.

Main Results:

  • UV light was confirmed to activate EGFR (ErbB1/ErbB2) both directly and indirectly.
  • Numerous extracellular and intracellular signaling intermediates are involved in UV-induced EGFR activation.
  • Key molecular changes observed include alterations in reactive oxygen species, hydrogen peroxide, matrix metalloproteinases, p38MAPKinase, p21WAF1, p53, signal transducers and activators of transcription 3, and telomerase.

Conclusions:

  • The findings clarify the intricate workings of the UV-EGFR signaling system in human skin.
  • This research highlights the importance of the UV-EGFR interaction in skin physiology and pathology.

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