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Updated: Jun 8, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Comparing biological therapies in psoriasis: implications for clinical practice.

C E M Griffiths¹

¹Dermatological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. christopher.griffiths@manchester.ac.uk

Journal of the European Academy of Dermatology and Venereology : JEADV

|September 14, 2010

Summary

Ustekinumab demonstrated superior clinical improvement for plaque psoriasis compared to etanercept in a head-to-head trial. This finding supports earlier and continuous systemic biologic therapy for managing moderate-to-severe psoriasis.

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Last Updated: Jun 8, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Immunology
Pharmacology

Background:

Severe plaque psoriasis treatment is often limited by traditional systemic therapy efficacy and safety.
Biological therapies targeting psoriasis pathophysiology offer a new paradigm for earlier, continuous systemic treatment.
Comparative trials for systemic psoriasis treatments are scarce.

Purpose of the Study:

To compare the efficacy of ustekinumab and etanercept in treating plaque psoriasis.
To establish ustekinumab as a superior biologic agent for plaque psoriasis management.

Main Methods:

The Active Comparator (CNTO 1275/Enbrel) Psoriasis Trial (ACCEPT) was a head-to-head superiority study.
Ustekinumab and etanercept were administered to patients with plaque psoriasis over a 12-week period.
Clinical improvement was assessed to compare treatment outcomes.

Main Results:

Ustekinumab achieved significantly superior clinical improvement compared to etanercept 50 mg twice weekly.
The observed response levels align with previous individual drug data.
The study provides robust comparative data on biologic agents for psoriasis.

Conclusions:

Ustekinumab offers a more effective treatment option for plaque psoriasis than etanercept.
Findings support the paradigm of earlier and continuous systemic biologic therapy in psoriasis management.
This study has significant implications for clinical practice in treating plaque psoriasis.