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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Channel Rhodopsins01:11

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

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Related Experiment Video

Updated: Jun 8, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

TRPC channels in pheromone sensing.

Kirill Kiselyov1, Damian B van Rossum, Randen L Patterson

  • 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Vitamins and Hormones
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Pheromone recognition involves G protein-coupled receptors (GPCR) and TRPC2 channels. Understanding TRPC2 activation mechanisms is key to ion channel physiology and behavioral pharmacology.

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Area of Science:

  • Neurobiology
  • Molecular Biology
  • Cell Physiology

Background:

  • Pheromone recognition is mediated by G protein-coupled receptors (GPCRs) initiating signaling cascades.
  • The transient receptor potential cation channel subfamily C member 2 (TRPC2) is crucial for translating GPCR activation into cellular responses in olfactory systems.
  • Canonical TRP (TRPC) channels, including TRPC2, regulate membrane permeability and ion (Ca2+) influx, impacting cellular signaling.

Purpose of the Study:

  • To review current knowledge on TRPC2 physiology.
  • To focus on the molecular mechanisms underlying TRPC2 activation.
  • To highlight the significance of TRPC2 in understanding ion channel function and behavior.

Main Methods:

  • Literature review of studies on TRPC2.
  • Analysis of data from TRPC2 research, including genetic studies.
  • Synthesis of findings related to TRPC channel activation mechanisms.

Main Results:

  • TRPC2 activation by pheromones is a primary example of TRPC channel physiological function.
  • Studies on TRPC2 have advanced the understanding of ion channel physiology and cell biology.
  • TRPC2 mutant mice exhibit altered sexual and social behaviors, underscoring its role.

Conclusions:

  • Despite its clear physiological role, the precise molecular mechanisms of TRPC2 activation remain incompletely understood.
  • Further research into TRPC2 activation mechanisms is expected to yield breakthroughs in ion channel physiology.
  • Understanding TRPC2 is vital for advancements in applied behavioral pharmacology.