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Insulin--binding antibodies in Nigerian diabetic patients
1Department of Medicine, University College Hospital, Ibadan.
The levels of insulin antibodies were determined in 68 diabetic patients on insulin treatment and 30 normal subjects. Fifty (73.5%) of the patients had low levels of insulin antibodies (less than 20%), twelve (17.7%) had moderate levels (between 20 and 40%) while the remaining six (8.8%) had high antibody levels (greater than 40%). There was poor correlation of insulin antibody level with insulin dose (r = 0.16, p less than 0.1) and with duration of disease (r = 0.19, p less than 0.5). Where high levels of antibodies were detected the problems encountered in treating the patients with highly purified insulin preparations are discussed.
The levels of insulin antibodies were determined in 68 diabetic patients on insulin treatment and 30 normal subjects. Fifty (73.5%) of the patients had low levels of insulin antibodies (less than 20%), twelve (17.7%) had moderate levels (between 20 and 40%) while the remaining six (8.8%) had high antibody levels (greater than 40%). There was poor correlation of insulin antibody level with insulin dose (r = 0.16, p less than 0.1) and with duration of disease (r = 0.19, p less than 0.5). Where high levels of antibodies were detected the problems encountered in treating the patients with highly purified insulin preparations are discussed.