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Updated: Jun 8, 2026

Recombinant Retroviral Production and Infection of B Cells
Published on: February 18, 2011
Epigenetic control of recombination in the immune system
Yehudit Bergman1, Howard Cedar
1Department of Developmental Biology and Cancer Research, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel. yehudit.bergman@huji.ac.il
None:
Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.
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