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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization
A Pogosyan1, F Yoshida, C C Chen
1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG UK.
Neuroscience
|September 14, 2010
Summary
Pathological brain synchronization in Parkinson's Disease (PD) is linked to motor deficits. Spatially extended beta-band synchronization in the subthalamic nucleus correlates with symptom severity, suggesting its role in PD progression.
Area of Science:
- Neuroscience
- Neurology
- Biomedical Engineering
Background:
- Pathological synchronization in the subthalamic nucleus (STN) is implicated in Parkinson's Disease (PD) motor impairment.
- Treatment-induced reduction of local beta-band oscillations correlates with motor improvement, but resting-state correlations are unclear.
Purpose of the Study:
- To investigate the relationship between spatially extended oscillatory synchronization and motor deficits in Parkinson's Disease.
- To assess the correlation of phase coherence in the STN with specific Parkinsonian motor symptoms.
Main Methods:
- Recorded local field potential (LFP) activity from STN using deep brain stimulation (DBS) electrode contacts in 18 PD patients.
- Measured phase coherence to quantify spatially extended oscillatory synchronization across different frequency bands.
- Correlated phase coherence with motor scores for bradykinesia, rigidity, and tremor.
Main Results:
- Beta-band phase coherence in the STN significantly correlated with the severity of limb and axial bradykinesia and rigidity.
- Correlations were frequency and site-specific, being reduced when the electrode was positioned above the dorsal STN.
- Sub-beta band frequencies showed lateralized correlations with limb tremor, distinct from beta-band findings.
Conclusions:
- Spatially extended oscillatory synchronization, particularly in the beta band, is a significant factor in Parkinsonian motor symptoms.
- Phase coherence measurements offer valuable insights for refining surgical targeting and stimulation strategies in PD.
- These findings strengthen the link between pathological synchronization and the diverse motor features of Parkinson's Disease.
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