Related Experiment Video
Updated: Jun 8, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
Published on: August 30, 2024
CST meets shelterin to keep telomeres in check
Marie-Josèphe Giraud-Panis1, M Teresa Teixeira, Vincent Géli
1Laboratory of Biology and Pathology of Genomes, University of Nice, CNRS UMR 6267, U998 INSERM, 28 Avenue Valombrose Faculté de Médecine, 06107 Nice, Cedex 2, France.
Abstract:
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
Related Concept Videos
Replicative Cell Senescence
Telomeres and Telomerase
Telomeres and Telomerase
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
The Spindle Assembly Checkpoint
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

