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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Related Experiment Video

Updated: Jun 8, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Osteocalcin and atherosclerosis: a complex relationship.

Rebeca Reyes García1, Pedro Rozas Moreno, Manuel Muñoz-Torres

  • 1Bone Metabolic Unit, RETICEF, Endocrinology Division, Hospital Universitario San Cecilio, Doctor Oloriz 18, 18010 Granada, Spain. rebecarg@yahoo.com

Diabetes Research and Clinical Practice
|September 14, 2010
PubMed
Summary

Osteocalcin (OC) plays a role in atherosclerosis by influencing the vascular system. Its effects on glucose metabolism and visceral fat highlight its contribution to cardiovascular disease development.

Related Experiment Videos

Last Updated: Jun 8, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Metabolic Research

Background:

  • Atherosclerosis is a complex cardiovascular disease with multifactorial origins.
  • The interplay between bone metabolism and vascular health is increasingly recognized.
  • Osteocalcin (OC) is a bone-derived hormone with potential systemic effects.

Purpose of the Study:

  • To investigate the relationship between osteocalcin (OC) and atherosclerosis in various clinical contexts.
  • To elucidate the role of OC in glucose metabolism and visceral fat regulation.
  • To understand OC's contribution to the pathogenesis of cardiovascular disease.

Main Methods:

  • The study examined the association between OC levels and atherosclerosis.
  • Effects of OC on glucose metabolism were assessed.
  • Impact of OC on visceral fat was evaluated in healthy and T2DM populations.

Main Results:

  • A significant relationship between OC and atherosclerosis was observed across different clinical situations.
  • OC demonstrated effects on glucose metabolism.
  • OC influenced visceral fat accumulation in both healthy individuals and those with type 2 diabetes mellitus (T2DM).

Conclusions:

  • Osteocalcin (OC) is implicated in the pathogenesis of atherosclerosis.
  • OC influences key metabolic factors relevant to cardiovascular disease.
  • These findings underscore the connection between bone health and vascular system function.