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Serum heart-type fatty acid binding protein levels in acromegaly patients

M Ozbek1, M Erdogan, M Dogan

  • 1Department of Endocrinology and Metabolism, Dıskapı Y.B. Education and Research Hospital, Ministry of Health, Ankara, Turkey.

Journal of Endocrinological Investigation
|September 14, 2010
PubMed

Insights

Serum heart-type fatty acid-binding protein (H-FABP) levels are elevated in acromegaly patients. Increased H-FABP may indicate impaired myocardial performance in individuals with acromegaly.

Area of Science:

  • Endocrinology
  • Cardiology
  • Biochemistry

Background:

  • Heart-type fatty acid-binding protein (H-FABP) is released upon myocardial injury.
  • H-FABP is linked to various cardiovascular and other conditions.

Purpose of the Study:

  • To investigate serum H-FABP levels in patients diagnosed with acromegaly.

Main Methods:

  • Serum H-FABP was measured using ELISA in 30 acromegaly patients and 55 controls.
  • Spearman's correlation test was employed.

Main Results:

  • Acromegaly patients exhibited significantly higher serum H-FABP levels compared to controls (17.40 ± 10.70 vs. 8.30 ± 7.20, p<0.001).
  • A positive correlation was observed between serum H-FABP and left ventricular end-systolic diameter (r=0.483, p=0.004).

Conclusions:

  • Patients with acromegaly demonstrate elevated serum H-FABP levels.
  • Serum H-FABP may serve as a biomarker for myocardial performance in acromegaly.
Abstract

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