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[Side effects of antibiotics in rheumatic diseases]
Abstract:
Complications due to antibiotic therapy in rheumatic patients subjected to season bicillin prophylaxis in Minsk within 1965--1975 and in patients with extensive collagenoses were studied. Allergic complications mainly ih the form of allergic reactions in the patients treated with bicillin-3 or picillin-5 were observed in 7.8--16.8 per cent of the patients. Within 10 years 52 cases of anaphylactic shock due to the bicillin use were recorded. Side reactions to antibiotics were observed in 16 (17.3 per cent) out of 92 patients with extensive collagenoses. For prophylaxis of the above complications it is recommended to use rational antibiotic therapy in rheumatic patients, strict registration of allergological states in the anamnesis, testing of microbial sensitivity to the antibiotics.
Insights
Antibiotic therapy, particularly penicillin, can cause allergic reactions in rheumatic patients and those with collagenoses. Careful patient history and sensitivity testing are crucial for preventing severe complications like anaphylactic shock.
Area of Science:
- Rheumatology
- Pharmacology
- Allergology
Context:
- Investigated complications of antibiotic therapy in rheumatic patients receiving seasonal penicillin prophylaxis (1965-1975, Minsk) and patients with extensive collagenoses.
- Focused on allergic reactions and side effects associated with penicillin G (bicillin-3, bicillin-5) use.
Purpose:
- To assess the incidence and nature of complications arising from antibiotic prophylaxis in specific patient groups.
- To identify risk factors and recommend strategies for preventing adverse drug reactions.
Summary:
- Allergic complications, including anaphylactic shock, were observed in 7.8-16.8% of rheumatic patients on penicillin prophylaxis.
- 17.3% of patients with extensive collagenoses experienced side reactions to antibiotics.
- 52 cases of anaphylactic shock linked to penicillin use were recorded over a decade.
Impact:
- Highlights the significant risk of allergic reactions to penicillin in vulnerable patient populations.
- Emphasizes the need for rational antibiotic use, thorough allergy screening, and microbial sensitivity testing.
- Informs clinical practice regarding the safe administration of antibiotic prophylaxis in rheumatology and collagenosis management.