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Related Experiment Video

Updated: Jun 8, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Angiogenesis and experimental hepatic fibrosis.

Queli Teixeira Lemos¹, Zilton A Andrade

¹Laboratório de Patologia Experimental,, Centro de Pesquisa Gonçalo Moniz, Fiocruz, Salvador, BA, Brasil.

Memorias Do Instituto Oswaldo Cruz

|September 14, 2010

Summary

Angiogenesis, the formation of new blood vessels, is a key process in liver repair and fibrosis. This study reveals its significant role across various experimental liver injury models.

Area of Science:

Hepatology
Vascular Biology
Pathology

Background:

Angiogenesis is crucial for granulation tissue repair and often precedes fibrosis in chronic liver diseases.
Understanding angiogenesis in hepatic insults is vital for comprehending liver disease progression.

Purpose of the Study:

To investigate the presence, development, and characteristics of angiogenesis in common experimental models of hepatic fibrosis.
To analyze cellular components, vascular structures, extracellular matrix, and associated molecular factors in these models.

Main Methods:

Examined five experimental models of liver fibrosis: Capillaria hepatica, pig serum, carbon tetrachloride, bile duct ligation (rats), and Schistosoma mansoni infection (mice).
Characterized cells, vessels, extracellular matrix, and investigated factors like factor VIII RA, vascular basement membrane, actin, elastin, and vascular-endothelial growth factor.

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Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

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Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

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Published on: September 13, 2016

Main Results:

All investigated models demonstrated significant angiogenesis.
A strong correlation between angiogenesis and fibrosis was observed, particularly in the Capillaria hepatica model.
Pericytes were noted to detach and transform into myofibroblasts, highlighting angiogenesis's role in fibrosis development.

Conclusions:

Angiogenesis is a prominent feature in diverse models of experimental liver fibrosis.
The transformation of pericytes into myofibroblasts underscores the critical role of angiogenesis in the pathogenesis of liver fibrosis.