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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Related Experiment Video

Updated: Jun 8, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Genome-wide DNA methylation profiling.

Marina Bibikova¹, Jian-Bing Fan¹

¹Illumina, Inc., 9885 Towne Centre Drive, San Diego, CA 92121, USA.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine

|September 14, 2010

Summary

This summary is machine-generated.

DNA methylation profiling technologies enable comprehensive genome-wide analysis of gene regulation. These methods are crucial for understanding cellular epigenetic mechanisms and environmental interactions.

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DNA Methylation: Bisulphite Modification and Analysis

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Area of Science:

Epigenetics
Genomics
Molecular Biology

Background:

DNA methylation is a key epigenetic regulator of gene expression.
Understanding DNA methylation is vital for deciphering gene regulation and cellular responses to the environment.

Purpose of the Study:

To review and categorize current DNA methylation profiling technologies.
To highlight the advancements in genome-wide methylation analysis.

Main Methods:

Overview of microarray and sequencing-based DNA methylation profiling.
Categorization based on methylation interrogation methods: bisulfite conversion, methylation-sensitive restriction enzymes, and methyl-binding proteins/antibodies.
Discussion of genome-wide bisulfite sequencing (WGBS) and reduced-representation methods.

Main Results:

Multiple technologies exist for DNA methylation profiling.
Next-generation sequencing has enabled comprehensive genome-wide bisulfite sequencing.
Various approaches provide detailed DNA methylation profiles across different organisms.

Conclusions:

Advanced DNA methylation profiling technologies are essential for understanding gene regulation.
Genome-wide bisulfite sequencing offers comprehensive insights into epigenetic mechanisms.
These technologies facilitate research into cellular epigenetic mechanisms and environmental interactions.