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Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Related Experiment Video

Updated: Jun 8, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

DNA methylation and gene expression.

Zahava Siegfried¹, Itamar Simon¹

¹Department of Microbiology and Molecular Genetics, The Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, 91120, Jerusalem, Israel.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine

|September 14, 2010

Summary

This summary is machine-generated.

DNA methylation, a key epigenetic process, regulates gene expression. Recent large-scale genomic studies reveal a dynamic and complex relationship between DNA methylation patterns and chromatin structure, offering new insights into gene regulation.

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Area of Science:

Epigenetics
Genomics
Molecular Biology

Background:

Cytosine methylation is a primary epigenetic modification in eukaryotes, typically silencing gene expression.
Mammalian genomes exhibit bimodal methylation, with CpG islands (CGIs) generally protected from methylation.

Purpose of the Study:

To review recent genomic studies on DNA methylation.
To elucidate the complex relationship between DNA methylation, chromatin structure, and gene expression.

Main Methods:

Large-scale DNA methylation mapping using advanced genomic technologies.
Analysis of correlations between methylation patterns, chromatin states, and gene expression levels.

Main Results:

Recent studies provide a dynamic view of DNA methylation's role in gene regulation.
Genomic-scale data reveal intricate associations between methylation, chromatin, and expression.

Conclusions:

DNA methylation's control over gene expression is more complex than previously understood.
Large-scale genomic studies are crucial for deciphering epigenetic regulatory mechanisms.