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Insulin-like growth factor-1 (IGF-1) is crucial for cell growth and development. This review examines IGF-1

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Area of Science:

  • Endocrinology and Metabolism
  • Skeletal Biology
  • Molecular Biology

Background:

  • Insulin-like growth factor-1 (IGF-1) is vital for cellular growth, differentiation, survival, and cell cycle progression.
  • IGF-1 mediates its effects via the insulin-like growth factor-1 receptor (IGF-1R).
  • IGF-binding proteins (IGFBPs) regulate IGF bioavailability and IGF-1R interaction.

Purpose of the Study:

  • To review findings on the IGF system using mouse models.
  • To discuss the clinical relevance of the IGF system in skeletal physiology.

Main Methods:

  • Review of existing literature and data from mouse models of the IGF system.

Main Results:

  • The IGF system plays critical roles in skeletal growth and development, as evidenced by animal models and human studies.
  • Mouse models provide valuable insights into the complex functions of IGF-1, IGF-1R, and IGFBPs.

Conclusions:

  • The IGF system is fundamental to normal and pathological skeletal physiology.
  • Understanding the IGF system through mouse models has significant clinical implications for bone health.